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ZIP-seq: genome-wide mapping of trinucleotide repeats at single-base resolution Free
Xingxing Xu1,2,†, Yonghui Tao1,2,†, Xing Fu1,†, Tao Yu1,2, Yuanyuan Li2,3, Kan Chen1, Xiaoyan Ding3, Kangcheng Ruan1, Naihe Jing3,*, and Ronggui Hu1,4,*
1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China
2University of Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China
3State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China
4Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China *Correspondence to:Naihe Jing, E-mail: njing@sibcb.ac.cn; Ronggui Hu, E-mail: coryhu@sibs.ac.cn
J Mol Cell Biol, Volume 6, Issue 1, February 2014, 93-96,  https://doi.org/10.1093/jmcb/mjt048

Dear Editor,

Repetitive DNA sequences, particularly the tandem repeats, are known to modulate gene expression and cause structural or functional variability in genes (Usdin, 2008; Gemayel et al., 2010). In addition to single-nucleotide polymorphisms and copy number variations, tandem repeat polymorphisms are increasingly recognized as another major dynamic source of genetic variability in health and disease (Hannan, 2010).


Volume 6, Issue 1
February 2014